MSM – More Information

I am not a physician, nor am I a clinical nutritionist. The information provided here is for educational purposes only. Any decision on your part to read and use this information is your personal choice. I do not recommend any of this be used on children.

Okay, I’m going to bore you to death and talk a little more about MSM. I decided to go directly to the PubMed database for my research into MSM. I did an advanced Google search on Methylsulfonylmethane (the chemical name for MSM) on the PubMed site. Here is a LINK (click here) to see all of the raw articles. I have pulled a few out here for this blog post. I am going to post some of this information and comment very little on it for now, I am still doing my research but though you might find some of this interesting.

MSM and it’s effect on Pain and Inflammation

Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis.

MSM significantly decreased the mean pain index from 1.53 +/- 0.51 to 0.74 +/- 0.65, and combination treatment resulted in a more significant decrease in the mean pain index (1.7 +/- 0.47 to 0.36 +/- 0.33; p < 0.001). After 12 weeks, the mean swelling index significantly decreased with Glu and MSM, while the decrease in swelling index with combination therapy was greater (1.43 +/- 0.63 to 0.14 +/- 0.35; p < 0.05) after 12 weeks. The combination produced a statistically significant decrease in the Lequesne index. All treatments were well tolerated. CONCLUSION: Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. All the treatments were well tolerated. The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis.

Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.

RESULTS: Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05). No notable changes were found in WOMAC stiffness and aggregated total symptoms scores. MSM also produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation (P<0.05). CONCLUSION: MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events. The benefits and safety of MSM in managing OA and long-term use cannot be confirmed from this pilot trial, but its potential clinical application is examined. Underlying mechanisms of action and need for further investigation of MSM are discussed.


MSM and it’s effect on the Sinuses and Respiratory System

A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis.

BACKGROUND: Seasonal allergic rhinitis (SAR) affects more than 23 million Americans annually, and current epidemiologic studies indicate that its prevalence within the United States is increasing.

RESULTS: Day 7 upper and total respiratory symptoms were reduced significantly from baseline (p < 0.01 and p < 0.005, respectively). Lower respiratory symptoms were significantly improved from baseline by week 3 (p < 0.001). All respiratory improvements were maintained through the 30-day visit. Energy levels increased significantly by day 14 (p < 0.0001); this increase continued through day 30. No significant changes were observed in plasma IgE or histamine levels. The results of this study are promising. It would be worthwhile to conduct a larger, randomized, double-blind, placebo-controlled study to establish further if MSM would be a useful agent in the treatment of symptoms associated with SAR. CONCLUSION: The results of this study suggest that MSM supplementation of 2,600 mg/day for 30 days may be efficacious in the reduction of symptoms associated with SAR. Furthermore, few side effects are associated with the use of this compound. Recent acute and subacute chronic toxicologic data on the same source of MSM as used in this study, further validate the safety of this product.

I find this part very interesting as there is a lot of evidence now that chronic sinus infections are the results of biofilms providing the perfect medium for bacteria and viruses to thrive. More on this later

MSM and it’s effect on an Incurable Skin Condition

Managing ichthyosis: a case study

Ichthyoses — rare, genetic, incurable dermatologic diseases characterized by dry, thickened, scaling skin — affect more than 1 million Americans and can cause devastating disfigurement with numerous physical, social, and emotional consequences. Topical treatments typically focus on symptom management. A 44-year-old man presented with severe X-linked type ichthyosis. When his condition did not improve with the use of a variety of topical and systemic treatments, a once-a-day, over-the-counter skin care regimen consisting of a surfactant-free cleanser followed by the application of moisturizer containing amino acids, vitamins, antioxidants, and methylsulfonylmethane (msm) was prescribed.

After 4 weeks of using this management regimen on a test area on his left arm, the skin was clear and discomfort and itching had subsided. Subsequent application of the skin care products on other affected areas also did not cause any adverse reactions and his skin continued to improve. Symptom resolution and patient satisfaction indicate the product line may be a viable consideration for use in patients with similarly compromised skin.

Interesting. A case of topical treatment using amino acids, vitamins, antioxidants and MSM to heal what they termed severe X- linked type ichthyosis. (Poor mans protocol in a skin care product?). Trish, you reading this, we gotta talk 😉 he he

MSM and it’s ability to penetrate cell membranes, the blood brain barrier, and aid in chelation

Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy.

Pharmacologic chelators do not effectively penetrate cell membranes and blood-brain barrier. This study assesses methylsulfonylmethane (MSM) as a permeability enhancer and an excipient to facilitate EDTA transport across biologic membranes, and to make possible localized, regional chelation. Topical application of MSM with C(14)EDTA onto the rat cornea led to uptake of the C(14)EDTA in all tested ocular tissues. Without MSM, EDTA did not penetrate the eye. The ability of MSM to deliver EDTA into an eye provides an opportunity for regional chelation therapy. Additionally, these studies suggest that MSM could also be an adjuvant for delivering ciprofloxacin and other chemical compounds to specific, local tissue sites.

Interesting, MSM allows chelators such as EDTA to pass into other biologic membranes that they couldn’t reach without the aid of MSM. Could this allow nutrients, vitamins, and amino acids to penetrate biofilms as well? Perhaps MSM’s role in PMP II will help carry nutrients to hard to get places (most likely biofilms) where things are hiding.

Sulfur in Human Nutrition

Sulfur in human nutrition and applications in medicine.

Because the role of elemental sulfur in human nutrition has not been studied extensively, it is the purpose of this article to emphasize the importance of this element in humans and discuss the therapeutic applications of sulfur compounds in medicine. Sulfur is the sixth most abundant macromineral in breast milk and the third most abundant mineral based on percentage of total body weight. The sulfur-containing amino acids (SAAs) are methionine, cysteine, cystine, homocysteine, homocystine, and taurine. Dietary SAA analysis and protein supplementation may be indicated for vegan athletes, children, or patients with HIV, because of an increased risk for SAA deficiency in these groups. Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, DMSO, and glucosamine sulfate. Organic sulfur, as SAAs, can be used to increase synthesis of S-adenosylmethionine (SAMe), glutathione (GSH), taurine, and N-acetylcysteine (NAC). MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Other sulfur compounds such as SAMe, dimethylsulfoxide (DMSO), taurine, glucosamine or chondroitin sulfate, and reduced glutathione may also have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS. Dosages, mechanisms of action, and rationales for use are discussed. The low toxicological profiles of these sulfur compounds, combined with promising therapeutic effects, warrant continued human clinical trails.

Finally, about the blood brain barrier, MSM has the ability to make it passed this barrier that stops most other things. You will find PubMed articles on this ability, and even its use causing effects on MRI scans of the brain, but as of yet, I have seen no claim this is harmful, but I am not a doctor.


Comments on: "MSM – More Information" (3)

  1. sherry Taylor said:

    This is great Mr. C, as I’m one of those people who likes to know why things work, Thank you. A chiropracter turned naturpath Dr. once prescribed msm to me but I didn’t understand the chemisty. I did try to make an msm cream and rub it on as a powder too a while is very I’m not sure how you mix it..but it was soothing..I fugures since I had some DMSO gel that msm cream might work too. Wish I knew how to make it. Sincerely, Sheryy

    • Shery,

      The MSM will only dissolve in water, not oil. According to this one company, it is okay to heat MSM (which is good if you are trying to make a cream).

      I experiment making my own creams from time to time and on occasion have added MSM to the water phase before adding the oil/emulsifier. I do not pretend to be any kind of an expert, but I think that if you are trying to get it past and INTO the skin, you need a carrier oil with the ability to do that. Emu oil is the only one that I am aware of that supposedly does that, though again, I am not an expert and maybe someone else has some insight into that.

      I don’t know if you can heat DMSO…though perhaps it can be added when the cream is cool, if it doesn’t change the texture too much. I haven’t tried that.

      For some reason I never found an MSM cream/lotion that I really liked. They must have other things in them that my skin doesn’t resonate with, but we are all different.


  2. Joe Keleher said:

    MSM being able to carry beyond the blood/brain barrier has me wondering. I think the cause and cure of Morgellons symptoms will rely on understanding this passage completely (including safe approaches so toxins do not build up in some other area of the body).

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